Synthesis of new bile acid analogues and their metabolism in the hamster: 3 alpha, 6 alpha-dihydroxy-6 beta-methyl-5 beta-cholanoic acid and 3 alpha, 6 beta-dihydroxy-6 alpha-methyl-5 beta-cholanoic acid.
نویسندگان
چکیده
منابع مشابه
Appearance of atypical 3 alpha,6 beta,7 beta,12 alpha-tetrahydroxy-5 beta-cholan-24-oic acid in spgp knockout mice.
Bile formation and its canalicular secretion are essential functions of the mammalian liver. The sister-of-p-glycoprotein (spgp) gene was shown to encode the canalicular bile salt export protein, and mutations in spgp gene were identified as the cause of progressive familial intrahepatic cholestasis type 2. However, target inactivation of spgp gene in mice results in nonprogressive but persiste...
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The mutagenicity of oxysterols, cholesterol-3beta,5alpha,6beta-triol (alpha-Triol), 7-keto-cholesterol (7-Keto) and cholesterol-5alpha,6alpha-epoxide (alpha-Epox) were examined by the Ames method and chromosome aberration test in this study. Only alpha-Triol concentration-dependently caused an increase of bacterial revertants in the absence of metabolic activating enzymes (S9), but not 7-keto a...
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Bile salts of ten species of frogs of the family Ranidae were examined by means of thin-layer chromatography, gas-liquid chromatography, and gas-liquid chromatography-mass spectrometry. Their major bile alcohols were ranol, cyprinol, or bufol. Four species of frogs contained lesser amounts of higher bile acids, and in two species C24 bile acids were present. A higher bile acid that has not been...
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In human keratinocytes cultured in conditions which allow differentiation and stratification and are suitable to reconstitute a fully functional epidermis, alpha 6 beta 4 and two members of the beta 1 integrin family (alpha 2 beta 1 and alpha 3 beta 1) were respectively polarized to the basal and lateral domains of the plasmamembrane both in growing colonies and in the reconstituted epidermis. ...
متن کاملBile Acids XXI. METABOLISM OF 3a,6~-DIHYDROXY-5~-CHOLANOIC ACID-24-‘4C-6a-“H IN THE RAT*
Our previous communication (2) reported the metabolism of lithocholic acid-24-W in the rat and the identification of chenodeoxycholic acid, 30(, 6/3-dihydroxy-5@-cholanoic acid, cy-muricholic acid, and P-muricholic acid as metabolites in the bile. Since previous studies (3) have shown that chenodeoxycholic acid is metabolized to QIand P-muricholic acids in the rat, chenodeoxycholic acid is prob...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1989
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)38288-2